Detailed Abstract
[E-poster]
[E16] Influence of liver fibrosis on prognosis after surgical resection for single hepatocellular carcinoma in patients with Child-Turcotte-Pugh A cirrhosis
Yoo Shin Choi, MD and Suk-Won Suh, MD
Department of Surgery, College of Medicine, Chung-Ang University, Seoul, Korea
Purpose
Surgical resection (SR) is recommended for single hepatocellular carcinoma (HCC) in patients with well-preserved liver function. However, unexpected liver fibrosis sometimes found at the SR which leads to a poor outcome. This study investigated the influence of liver fibrosis on prognosis after SR for HCC.
Methods
A total of 189 patients with CTP A cirrhosis who underwent curative SR for a single HCC < 5 cm were evaluated. Patients were assigned to two groups based on the degree of fibrosis (mild or severe), as determined by histological evaluation.
Results
Severe fibrosis was present in 49 patients (25.9 %); these patients had greater postoperative liver insufficiency (P = 0.000) and HCC recurrence (P = 0.016). Severe liver fibrosis (hazard ratio [HR] = 1.849, 95% confidence interval [CI] 1.191–2.869; P = 0.006), microvascular invasion (HR = 1.854, 95% CI 1.183–2.906; P = 0.007), and poor histologic grade (HR = 2.097, 95% CI 1.230–3.574; P = 0.007) were related to HCC recurrence.
Conclusion
Severe fibrosis can found even in patients with well-preserved liver function and it leads poorer early postoperative and late oncologic outcomes, therefore it should be considered before SR for HCC.